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Important Safety Information EPIVIR, like other HIV medicines, can cause condition called lactic acidosis and severe liver problems. Increased early embryolethality occurred in rabbits at exposure levels similar to those in humans. Total exposure to lamivudine, as reflected by mean AUC values, was comparable between pediatric patients receiving an 8-mg epivir verkoop kg day dose and adults receiving 4-mg kg day dose. Study EPV40001: Fifty patients received zidovudine 300 mg twice daily plus abacavir 300 mg twice daily plus lamivudine 300 mg once daily and 50 patients received zidovudine 300 mg plus abacavir 300 mg plus lamivudine 150 mg all twice daily.
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